Health Science Futures (HSF) Mission Office Innovative Solutions Opening (ISO)
Department of Health and Human Services · National Institutes of Health · ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H)
Account requiredWhy it scored this way
Every reason behind the verdict rather than the headline one — which of your certifications match, how much runway is left, whether the work is your size, and what we would need to know to sharpen it.
Written against this notice and what you have told us about your company. Anything we do not know is marked [NEEDS INPUT] in the draft rather than guessed at — read it before you send it.
Start a free trial to draft these. Nothing is sent to an agency on your behalf, ever — you get a document to review, edit and submit yourself.
Compliance matrix
Every stated and implied requirement, its source section, whether it is mandatory, and where your response will address it.
Proposal outline
A submission skeleton where every required element is a heading with its source requirement quoted beneath it. You write the substance; nothing gets forgotten.
Questions to submit
Genuine ambiguities and requirements that disadvantage a smaller bidder, drafted as questions you can submit before the Q&A deadline.
Past performance write-ups
Which of your prior awards best match this requirement, and draft write-ups in the format the agency asked for.
Solicitation details
Solicitation number
ARPA-H-SOL-24-104
Notice type
Solicitation
NAICS
541715
Product service code
AN13
Set-aside
Unrestricted
Posted
2026-01-08
Response deadline
Mar 6, 2029, 4:59 AM UTC
Contracting contact
do_NOT_use_THIS_email_ADDRESS@arpa-h.gov
Market intelligence
Account requiredWho wins this work, and what it pays
Comparable awards under NAICS 541715 at this agency — the incumbent, what they were paid, when their period of performance ends, and the real pricing distribution rather than the headline number. From public federal award records.
This ISO seeks solution summaries and proposal submissions for projects that fall within the general scope of the ARPA-H Health Science Futures (HSF) mission office. HSF expands what is technically possible by developing approaches that will remove the scientific and technological limitations that stymie progress towards the healthcare of the future. HSF supports cutting-edge, often disease-agnostic research programs that have the potential for translational real-world change. Solution summary submissions must be submitted to: https://solutions.arpa-h.gov Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/ Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/ Amendment 3 is effective immediately; however, if an entity has previously submitted a solution summary and/or a proposal, the prior solicitation(s) will be followed for those submissions. If a solution summary is submitted; however, a proposal has not been submitted yet, the proposal will be evaluated in accordance with this amendment. The following updates were made to the proposal documents: 1) Administrative & National Policy Requirements Document Updated the instructions and references within the “Organizational Conflicts of Interest (OCI) Affirmations and Disclosure” section. Updated questions, instructions, and content within the “Research Security Disclosure” section. Updated the instructions and intellectual property data assertions charts within the “IP” section. This included providing definitions of rights categories (unlimited, government purpose, limited, and specially negotiated/other) and consolidating two data assertions charts into one to assist proposers more efficiently complete the document. Specifically, the “Non-Commercial” and “Commercial” tables were removed and replaced with the “Background IP and Data Assertions” table. Eliminated the “Software Component Standards” section. Updated the Human Subjects Research (HSR) table within the “HSR” section. Updated the Animal Subjects Research (ASR) table within the “ASR” section. Updated the questions and instructions within the “Biosecurity” section. 2) Cost Proposal Document (Word document) Updated the instructions within the “Level of Effort and Labor Costs” section. Added definitions for “burdened labor rate” and “fully burdened labor rate” to provide clarity for proposers when completing the document. Also added a statement to clarify that fully burdened labor rates are not used in the Cost Proposal Workbooks. Increased the threshold for proposers to provide supporting documentation with their proposal for planned materials and equipment purchases based on unit cost. The unit cost threshold was increased from $5,000 to $10,000. 3) Cost Proposal Workbooks (Excel spreadsheets) Updated instructions to clarify that ARPA-H will assume profit/fee is not applicable for proposals if proposers do not include profit/fee in the workbook. Updated the instructions for supporting documentation associated with planned materials and equipment purchases (based on the unit cost threshold increasing from $5,000 to $10,000). Completed administrative update to a tab
Contact
Point of contact
SEE DESCRIPTION SECTION
Role
not stated on this notice — SAM publishes a role for only about 5% of them, so this may be a contract specialist rather than the contracting officer
Email
do_NOT_use_THIS_email_ADDRESS@arpa-h.gov
Submit questions
Ambiguities and requirements worth clarifying, written as questions you can send before the deadline.
Opens in your own mail client, addressed and with a subject line — you write the message. GovSprint never sends anything on your behalf.
Emails open in your mail client and are sent from your address, so the reply comes back to you and the exchange stays yours. Confirm the correct channel and any question deadline on the notice before sending — many solicitations require questions in a specific way.
