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Protein ENGineering (PENG)

Department of Defense · Defense Advanced Research Projects Agency (DARPA) · DEF ADVANCED RESEARCH PROJECTS AGCY
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Solicitation details

Solicitation number
DARPA-PS-26-129
Notice type
Solicitation
NAICS
541714
Product service code
AC12
Set-aside
Unrestricted
Posted
2026-08-07
Response deadline
Oct 19, 2026, 9:00 PM UTC
Contracting contact
PENG@darpa.mil

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Statement of work, as posted

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals for the development of a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins. The goal of the Protein ENGineering (PENG) program is to transition proteome engineering from a collection of isolated, bespoke tools into a universal, software-defined discipline. The PENG program will establish a comprehensive, integrated platform composed of modular targeting, generalizable effector chemistries, and multiplexed control systems. Rather than developing isolated, target-specific tools, performers will integrate novel splicing, ligation, and co-translational techniques to directly recognize, modify, and rewrite endogenous proteins within complex biological architectures. Performers may explore multiple technical paths, progressively advancing their approaches from foundational validation to robust demonstrations of efficacy. Ultimately, this integrated platform will be validated in high-fidelity cellular models (e.g., organoids), to provide an integrated proof-of-concept at the tissue level.

Contact

Point of contact
BAA Coordinator
Role
not stated on this notice — SAM publishes a role for only about 5% of them, so this may be a contract specialist rather than the contracting officer
Email
PENG@darpa.mil
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